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By Shaul G. Massry (auth.), Severin Ringoir, Raymond Vanholder, Shaul G. Massry (eds.)

The current publication includes the complaints of a day Symposium on Uremic pollutants prepared on the college of Ghent in Belgium. a chain of visitor lectures, unfastened communications and posters were offered. a world viewers of 163 scientists from sixteen nationalities listened to and mentioned generally a spectrum of issues introduced ahead via colleagues and researchers who labored for a few years within the box of Uremic pollutants. there's a impressive distinction among all of the new dialysis thoughts to be had within the paintings to "clean" the uremic sufferers and the just about non-progression of our wisdom on uremic pollution some time past decade. during this feel the symposium was once felt by way of all contributors as a brand new commence for the study within the biochemical box of the definition of uremia. If the current quantity may stimulate new paintings during this box so that it will outline uremia, or establish the uremic pollutants, the aim of the organizers will be maximally fulfilled.

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J. B. N. P. J. H. Aniuk. Solutizers as an adjunct to artificial organ treatment for bound chemicals. Trans. Am. Soc. Artif. Int. Organs, Vol. XXVI:116 (1980). A. A. Sargent. A mechanistic analysis of the National Cooperative Dialysis Study (NCDS). , 28:526 (1985). L. J. A. Uvelli, J. H. Scribner. Quantitative description of dialysis treatment: A dialysis index. , 5:23 (1975). MIDDLE IDLOCULES AND THE 7 C FACI'OR Jonas Bergstran, Hans Jornvall, and Lena Zirrmerman Karolinska Institute Department of Renal Medicine Huddinge University Hospital S-141 86 Huddinge Sweden Background Soon after Babb and Scribner in 19721 presented The Middle Molecule Hypothesis several investigators performed clinical studies in dialysis patients, designed to increase or decrease the presumed level of middle molecules (MM) in the body fluids relating these changes to the symptomatology of the patients or to the in vitro toxicity of plasma and dialysate (see references in 1).

We observed higher levels of the free fractions of tryptophan and indican postdialysis, compared to predialysis sera 7 , in almost all patients studied. This means that heparin already, in a way, may act as a solutizer. This also may relativize a little the very flat curve of clearance versus blood flow (Fig. 3a) for indican and other solutes, as the extent of protein binding decreases during dialysis. The reverse is true for hippuric acid, as protein binding was found to be increasing during dialysis (Table 2), in accordance with data reported by Farrell 10 .

Hikkers, C. Cramers, R. De Smet, and S. Ringoir. Uremic toxins and the elusive middle molecules. Nephron 38:1 (1984). P. Furst, J. Bergstrom, A. Gordon, E. Johnsson and L. Zimmerman. Separation of peptides of 'middle' molecular weight from biological fluids of patients with uremia. , 7:272 (1975). L. K. Han, A. Sausse, J. Zingraff, J. Boudet, A. F. Cueille. Characterization of a 1100-1300 KW uremic neurotoxin. Trans. Am. Soc. Artif. Int. Organs, 22:163 (1976). C. P. A. C1aessens, R. De Smet, N.

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