Download Mycobacterium tuberculosis: Interactions with the Immune by L. F. Affronti (auth.), Mauro Bendinelli, Herman Friedman PDF

By L. F. Affronti (auth.), Mauro Bendinelli, Herman Friedman (eds.)

Tuberculosis once more occupies a unique place within the components of infec­ tious ailments and microbiology. This sickness has been very important to mankind in view that even prior to biblical instances. Tuberculosis has been an immense reason for morbidity and mortality in people, in particular in hugely ur­ banized Europe, until eventually a number of many years in the past. certainly, this ailment grew to become a middle of many novels, performs, and operas, because it really renowned to have the heroine demise of "consumption. " most significantly, tuberculosis additionally turned the focal point of realization for plenty of investigations throughout the nineteenth or even the 20 th centuries. significant advances have been made within the parts of isolation and identity of M. tuberculosis and similar microorganisms. the invention, via Robert Koch, that tuberculosis used to be brought on by an infectious agent revolutionized our puzzling over dis­ eases. Koch's postulates have been built with tuberculosis in brain and have become a focus for plenty of advances in microbiology and medication. stories with mycobacteria as a vital concentration have additionally ended in revolu­ tionary new options approximately immunology ordinarily. Koch himself confirmed that these uncovered to M. tuberculosis improve a epidermis hypersen­ sitivity or hypersensitive reaction to the microorganism's antigens, an remark which was once the place to begin for lots of vital advancements. certainly, imme­ diate-type allergy and atopic or IgE-mediated allergic reaction have been de­ fined when it comes to the delayed-type cutaneous hypersensitive reaction evi­ denced with the tubercle bacillus.

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V\' .. Goldstein, R. A .. and Aron, S. , 1971, Immunoelectrophoretic studies of the precipitating antibody response in tuberculosis, Am. Rev. Respir. l. 103:894. 48. Janicki, B. , Aron, S. , Schechter, G. , 1972, Tuberculin antigens active in human lymphocyte blastogenesis, Proc. Soc. Exp. Bioi. lHed. 141:809-813. 49. Janicki, B. , and Aron, S. , 1973, Failure of isolated tuberculopolysaccharides to induce precipitins in the guinea pig, AmlU. Mig. Alii. Soc. ,Hicrobiol. ). 50. Janicki, B. , Goldstein, R.

141:809-813. 49. Janicki, B. , and Aron, S. , 1973, Failure of isolated tuberculopolysaccharides to induce precipitins in the guinea pig, AmlU. Mig. Alii. Soc. ,Hicrobiol. ). 50. Janicki, B. , Goldstein, R. , and Aron, S. , 1971, Immunoelectrophoretic studies of the precipitating antibody response in tuberculosis, Alii. Rev. lpir. Dis. ). 51. , and Wisnieski, J. , 1970, The reaction of concanavalin A with mycobacterial culture filtrates, Am. Rev. Respir. Dis. 101:762-764. 52. , 1974, The purification of mycobacterial polysaccharides with concanavalin A, Am.

W_ ...... x ___ ..... 4 ...... x ..... _. -.. -. 2 1 2 (5,1lg / ml) 3 4 5 6 7 8 910 11 ANTIGEN DILU TION FIGURE 3. Comparison of antibody levels using different mycobacterial antigen fractions against a tuberculous referenc e system. (From Affronti 104 ) 26 L. F. ,105 using tuberculoproteins A and C to measure the amount of reactive IgG in the sera from advanced and moderately advanced tuberculosis patients, leprosy patients, and normal individuals. The A protein detected significant levels of IgG antibodies in patients with both advanced and moderately advanced disease and in patients with leprosy.

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