By Karsten Schrör
Written via a number one specialist on Aspirin-related learn, this can be the main finished treatise at the pharmacological results and scientific purposes of 1 of the main winning medicinal drugs ever.
The textual content is written with a large viewers in brain, and to be easily comprehensible for clinicians, pharmacists, biomedical researchers and pharmacologists alike.
This moment, thoroughly revised variation includes the most recent result of medical and pharmacological examine on Acetylsalicylic acid, addressing the a number of pharmacological homes of this well-known drug with a balanced view on their translation into scientific perform, together with prevention from cardiovascular illnesses and colorectal cancer.
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Sci. USA, 96 (9), 5292–5297. A. et al. (2005) Inhibition of p90 ribosomal S6 kinase-mediated CCAAT/enhancer-binding protein beta activation and cyclooxygenase-2 expression by salicylate. J. Biol. , 280 (18), 18411–18417. 1 Anti-Inﬂammatory/Analgesic Actions The disclosure of a causal relationship between inhibition of prostaglandin synthesis and the antipyretic and anti-inﬂammatory actions of aspirin provided an attractive explanation for its therapeutic efﬁcacy in the treatment of inﬂammatory and feverish diseases.
This fundamental ﬁnding was acknowl edged with the Young Researchers’ Aspirin Award in 2005. Salicylates and Gene Transcription Kenneth K. 3-3) and his group were the ﬁrst to show that both aspirin and salicylate can interact with the binding of transcription factors to the promoter region of the COX-2 gene. 3-3 Kenneth K. Wu. 1 History mediators in many cell types, including white cells and endothelial cells [24,25]. Later work of this group eventually identiﬁed salicylate-induced phosphorylation of CCAAT/enhancer-binding protein-β (C/EBP-β or NF/IL-6) as the critical factor [19,26].
According to a German registry (MONICA registry), salicylates still keep a key position (70–80%) in OTC drugs for these indica tions . Actually, aspirin has to compete in these indications with ibuprofen and the non-anti inﬂammatory acetaminophen, but it still does very well . 3. 4-1 Turnover rates for Bayer Aspirin from 1899 to 2005 (projected) in millions of DM (Deutsche Mark). 7. (After Ref. ). 2), bleedings were not considered a seri ous clinical problem by the vast majority of individuals, who took aspirin only once or for a few days to treat headache and symptoms of ﬂu or other feverish discomfort.